Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.
Identifieur interne : 000140 ( Main/Exploration ); précédent : 000139; suivant : 000141Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.
Auteurs : Mark Loeb [Canada] ; Margaret L. Russell [Canada] ; Vanessa Manning [Canada] ; Kevin Fonseca [Canada] ; David J D. Earn [Canada] ; Gregory Horsman [Canada] ; Khami Chokani [Canada] ; Mark Vooght [Canada] ; Lorne Babiuk [Canada] ; Lisa Schwartz [Canada] ; Binod Neupane [Canada] ; Pardeep Singh [Canada] ; Stephen D. Walter [Canada] ; Eleanor Pullenayegum [Canada]Source :
- Annals of internal medicine [ 1539-3704 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Canada (épidémiologie), Enfant, Enfant d'âge préscolaire, Grippe humaine (), Grippe humaine (épidémiologie), Humains, Immunité de groupe, Population rurale, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins atténués (administration et posologie), Vaccins atténués (effets indésirables), Vaccins inactivés (administration et posologie), Vaccins inactivés (effets indésirables).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés.
- effets indésirables : Vaccins antigrippaux, Vaccins atténués, Vaccins inactivés.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Grippe humaine, Humains, Immunité de groupe, Population rurale, Vaccination.
English descriptors
- KwdEn :
- Adolescent, Canada (epidemiology), Child, Child, Preschool, Humans, Immunity, Herd, Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Rural Population, Vaccination, Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (adverse effects), Vaccines, Inactivated (administration & dosage), Vaccines, Inactivated (adverse effects).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- chemical , adverse effects : Influenza Vaccines, Vaccines, Attenuated, Vaccines, Inactivated.
- epidemiology : Canada, Influenza, Human.
- prevention & control : Influenza, Human.
- Adolescent, Child, Child, Preschool, Humans, Immunity, Herd, Rural Population, Vaccination.
Abstract
Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effective than inactivated influenza vaccine (IIV) in providing both direct protection in vaccinated persons and herd protection in unvaccinated persons is uncertain. Hutterite colonies, where members live in close-knit, small rural communities in which influenza virus infection regularly occurs, offer an opportunity to address this question.
DOI: 10.7326/M16-0513
PubMed: 27538259
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.</title><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Manning, Vanessa" sort="Manning, Vanessa" uniqKey="Manning V" first="Vanessa" last="Manning">Vanessa Manning</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J D" last="Earn">David J D. Earn</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Horsman, Gregory" sort="Horsman, Gregory" uniqKey="Horsman G" first="Gregory" last="Horsman">Gregory Horsman</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chokani, Khami" sort="Chokani, Khami" uniqKey="Chokani K" first="Khami" last="Chokani">Khami Chokani</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Vooght, Mark" sort="Vooght, Mark" uniqKey="Vooght M" first="Mark" last="Vooght">Mark Vooght</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Babiuk, Lorne" sort="Babiuk, Lorne" uniqKey="Babiuk L" first="Lorne" last="Babiuk">Lorne Babiuk</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Schwartz, Lisa" sort="Schwartz, Lisa" uniqKey="Schwartz L" first="Lisa" last="Schwartz">Lisa Schwartz</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Neupane, Binod" sort="Neupane, Binod" uniqKey="Neupane B" first="Binod" last="Neupane">Binod Neupane</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Pardeep" sort="Singh, Pardeep" uniqKey="Singh P" first="Pardeep" last="Singh">Pardeep Singh</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Walter, Stephen D" sort="Walter, Stephen D" uniqKey="Walter S" first="Stephen D" last="Walter">Stephen D. Walter</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pullenayegum, Eleanor" sort="Pullenayegum, Eleanor" uniqKey="Pullenayegum E" first="Eleanor" last="Pullenayegum">Eleanor Pullenayegum</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27538259</idno><idno type="pmid">27538259</idno><idno type="doi">10.7326/M16-0513</idno><idno type="wicri:Area/Main/Corpus">000120</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000120</idno><idno type="wicri:Area/Main/Curation">000120</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000120</idno><idno type="wicri:Area/Main/Exploration">000120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.</title><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Manning, Vanessa" sort="Manning, Vanessa" uniqKey="Manning V" first="Vanessa" last="Manning">Vanessa Manning</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J D" last="Earn">David J D. Earn</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Horsman, Gregory" sort="Horsman, Gregory" uniqKey="Horsman G" first="Gregory" last="Horsman">Gregory Horsman</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Chokani, Khami" sort="Chokani, Khami" uniqKey="Chokani K" first="Khami" last="Chokani">Khami Chokani</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Vooght, Mark" sort="Vooght, Mark" uniqKey="Vooght M" first="Mark" last="Vooght">Mark Vooght</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Babiuk, Lorne" sort="Babiuk, Lorne" uniqKey="Babiuk L" first="Lorne" last="Babiuk">Lorne Babiuk</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Schwartz, Lisa" sort="Schwartz, Lisa" uniqKey="Schwartz L" first="Lisa" last="Schwartz">Lisa Schwartz</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Neupane, Binod" sort="Neupane, Binod" uniqKey="Neupane B" first="Binod" last="Neupane">Binod Neupane</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Pardeep" sort="Singh, Pardeep" uniqKey="Singh P" first="Pardeep" last="Singh">Pardeep Singh</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Walter, Stephen D" sort="Walter, Stephen D" uniqKey="Walter S" first="Stephen D" last="Walter">Stephen D. Walter</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Pullenayegum, Eleanor" sort="Pullenayegum, Eleanor" uniqKey="Pullenayegum E" first="Eleanor" last="Pullenayegum">Eleanor Pullenayegum</name><affiliation wicri:level="1"><nlm:affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of internal medicine</title><idno type="eISSN">1539-3704</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Canada (epidemiology)</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Immunity, Herd</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Rural Population</term><term>Vaccination</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (adverse effects)</term><term>Vaccines, Inactivated (administration & dosage)</term><term>Vaccines, Inactivated (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Canada (épidémiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine ()</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Immunité de groupe</term><term>Population rurale</term><term>Vaccination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins atténués (administration et posologie)</term><term>Vaccins atténués (effets indésirables)</term><term>Vaccins inactivés (administration et posologie)</term><term>Vaccins inactivés (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term><term>Vaccines, Inactivated</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Canada</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Canada</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Humans</term><term>Immunity, Herd</term><term>Rural Population</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Grippe humaine</term><term>Humains</term><term>Immunité de groupe</term><term>Population rurale</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effective than inactivated influenza vaccine (IIV) in providing both direct protection in vaccinated persons and herd protection in unvaccinated persons is uncertain. Hutterite colonies, where members live in close-knit, small rural communities in which influenza virus infection regularly occurs, offer an opportunity to address this question.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27538259</PMID><DateCompleted><Year>2017</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1539-3704</ISSN><JournalIssue CitedMedium="Internet"><Volume>165</Volume><Issue>9</Issue><PubDate><Year>2016</Year><Month>Nov</Month><Day>01</Day></PubDate></JournalIssue><Title>Annals of internal medicine</Title><ISOAbbreviation>Ann. Intern. Med.</ISOAbbreviation></Journal><ArticleTitle>Live Attenuated Versus Inactivated Influenza Vaccine in Hutterite Children: A Cluster Randomized Blinded Trial.</ArticleTitle><Pagination><MedlinePgn>617-624</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7326/M16-0513</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effective than inactivated influenza vaccine (IIV) in providing both direct protection in vaccinated persons and herd protection in unvaccinated persons is uncertain. Hutterite colonies, where members live in close-knit, small rural communities in which influenza virus infection regularly occurs, offer an opportunity to address this question.</AbstractText><AbstractText Label="Objective" NlmCategory="UNASSIGNED">To determine whether vaccinating children and adolescents with LAIV provides better community protection than IIV.</AbstractText><AbstractText Label="Design" NlmCategory="UNASSIGNED">A cluster randomized blinded trial conducted between October 2012 and May 2015 over 3 influenza seasons. (ClinicalTrials.gov: NCT01653015).</AbstractText><AbstractText Label="Setting" NlmCategory="UNASSIGNED">52 Hutterite colonies in Alberta and Saskatchewan, Canada.</AbstractText><AbstractText Label="Participants" NlmCategory="UNASSIGNED">1186 Canadian children and adolescents aged 36 months to 15 years who received the study vaccine and 3425 community members who did not.</AbstractText><AbstractText Label="Intervention" NlmCategory="UNASSIGNED">Children were randomly assigned according to community in a blinded manner to receive standard dosing of either trivalent LAIV or trivalent IIV.</AbstractText><AbstractText Label="Measurements" NlmCategory="UNASSIGNED">The primary outcome was reverse transcriptase polymerase chain reaction-confirmed influenza A or B virus in all participants (vaccinated children and persons who did not receive the study vaccine).</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Mean vaccine coverage among children in the LAIV group was 76.9% versus 72.3% in the IIV group. Influenza virus infection occurred at a rate of 5.3% (295 of 5560 person-years) in the LAIV group versus 5.2% (304 of 5810 person-years) in the IIV group. The hazard ratio comparing LAIV with IIV for influenza A or B virus was 1.03 (95% CI, 0.85 to 1.24).</AbstractText><AbstractText Label="Limitation" NlmCategory="UNASSIGNED">The study was conducted in Hutterite communities, which may limit generalizability.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Immunizing children with LAIV does not provide better community protection against influenza than IIV.</AbstractText><AbstractText Label="Primary Funding Source" NlmCategory="UNASSIGNED">The Canadian Institutes for Health Research.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Loeb</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Russell</LastName><ForeName>Margaret L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manning</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fonseca</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Earn</LastName><ForeName>David J D</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horsman</LastName><ForeName>Gregory</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chokani</LastName><ForeName>Khami</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vooght</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Babiuk</LastName><ForeName>Lorne</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Lisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neupane</LastName><ForeName>Binod</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Pardeep</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walter</LastName><ForeName>Stephen D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pullenayegum</LastName><ForeName>Eleanor</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>From McMaster University, Hamilton, Ontario; University of Calgary, Calgary, Alberta; Saskatchewan Disease Control Laboratory, Regina, Saskatchewan; Prince Albert Parkland Health Region, Prince Albert, Saskatchewan; Five Hills Health Region, Moose Jaw, Saskatchewan; and Hospital for Sick Children, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01653015</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Intern Med</MedlineTA><NlmUniqueID>0372351</NlmUniqueID><ISSNLinking>0003-4819</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014613">Vaccines, Attenuated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015164">Vaccines, Inactivated</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032521" MajorTopicYN="N">Immunity, Herd</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012424" MajorTopicYN="N">Rural Population</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014613" MajorTopicYN="N">Vaccines, Attenuated</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015164" MajorTopicYN="N">Vaccines, Inactivated</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27538259</ArticleId><ArticleId IdType="pii">2543271</ArticleId><ArticleId IdType="doi">10.7326/M16-0513</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name></noRegion><name sortKey="Babiuk, Lorne" sort="Babiuk, Lorne" uniqKey="Babiuk L" first="Lorne" last="Babiuk">Lorne Babiuk</name><name sortKey="Chokani, Khami" sort="Chokani, Khami" uniqKey="Chokani K" first="Khami" last="Chokani">Khami Chokani</name><name sortKey="Earn, David J D" sort="Earn, David J D" uniqKey="Earn D" first="David J D" last="Earn">David J D. Earn</name><name sortKey="Fonseca, Kevin" sort="Fonseca, Kevin" uniqKey="Fonseca K" first="Kevin" last="Fonseca">Kevin Fonseca</name><name sortKey="Horsman, Gregory" sort="Horsman, Gregory" uniqKey="Horsman G" first="Gregory" last="Horsman">Gregory Horsman</name><name sortKey="Manning, Vanessa" sort="Manning, Vanessa" uniqKey="Manning V" first="Vanessa" last="Manning">Vanessa Manning</name><name sortKey="Neupane, Binod" sort="Neupane, Binod" uniqKey="Neupane B" first="Binod" last="Neupane">Binod Neupane</name><name sortKey="Pullenayegum, Eleanor" sort="Pullenayegum, Eleanor" uniqKey="Pullenayegum E" first="Eleanor" last="Pullenayegum">Eleanor Pullenayegum</name><name sortKey="Russell, Margaret L" sort="Russell, Margaret L" uniqKey="Russell M" first="Margaret L" last="Russell">Margaret L. Russell</name><name sortKey="Schwartz, Lisa" sort="Schwartz, Lisa" uniqKey="Schwartz L" first="Lisa" last="Schwartz">Lisa Schwartz</name><name sortKey="Singh, Pardeep" sort="Singh, Pardeep" uniqKey="Singh P" first="Pardeep" last="Singh">Pardeep Singh</name><name sortKey="Vooght, Mark" sort="Vooght, Mark" uniqKey="Vooght M" first="Mark" last="Vooght">Mark Vooght</name><name sortKey="Walter, Stephen D" sort="Walter, Stephen D" uniqKey="Walter S" first="Stephen D" last="Walter">Stephen D. Walter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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